Honigmann Lab

Selected publications highlighting major advances from our laboratory.

• Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions (2019) Cell
  Discovered that ZO scaffold proteins undergo phase separation to assemble the cytoplasmic tight junction scaffold.


• Membrane prewetting by condensates promotes tight-junction belt formation (2024) Nature
  Demonstrated how condensation of ZO proteins is spatially constrained to form the tight junction belt.


• Assembly of tight junction belts by ZO1 surface condensation and local actin polymerization (2025) Developmental Cell
  Revealed how ZO1 surface condensation and local actin polymerization cooperate to drive the growth of tight-junction belts.


• Tight junctions control lumen morphology via hydrostatic pressure and junctional tension (2024) Developmental Cell
  Showed that tight junction mechanics regulate hydrostatic pressure and tissue tension to shape epithelial lumen morphology during epithelial morphogenesis.


• Quantitative imaging of lipid transport in mammalian cells (2025) Nature
  Established the first imaging approach that directly visualizes and measures lipid localization and transport in mammalian cells.

All Publications